Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder. The metabolic aspect of disorder is characterized by obesity-related risk factors for cardiovascular disease. The aim of this study was to determine in women with PCOS, indices of lipid metabolism and their oxidation, and to assess possible relation to insulin resistance. We investigated 75 women with PCOS (age: 23.1±5.1 years, body mass index (BMI): 24.9±4.7 kg/m2) and 56 age an...

We describe a 52-year-old woman, with acromegaly, clival chondroid chordoma, meningioma and lung carcinoid. There was no family history of MEN-1. She was diagnosed as acromegaly in 2000. Radiological evaluation (MRI) revealed pituitary tumor, however, another infiltration of scull base was detected which invaded sphenoidal and ethmoidal sinuses, lamina cribroza and bilateral orbit walls. Pituitary tumor was completely removed and the reduction of extra-sellar mass was performe...

The diagnosis of adult growth hormone deficiency (GHD) in patients with pituitary disease relies predominantly on provocative tests of GH secretion. The incidence of GHD in treated acromegalic patients has not been fully documented. Therefore, the aim of the present study was to elucidate GH response to insulin-induced hypoglycaemia (ITT, 0.15 IU/kg i.v.) in a cohort of 10 patients with acromegly considered cured solely by transsphenoidal surgery (6 females and 4 males, mean a...

Introduction: Cortisol has important roles in the regulation of body composition and hypercortisolaemia have major impact on body fat distribution. The aim of this study was to analyze differences in adipose tissue distribution in women with Cushing’s disease and Cushing’s syndrome due to adrenal adenoma.Method: We evaluated 12 women with Cushing’s syndrome, six with ACTH secreting pituitary adenomas (Group A) and six with adrenal adenomas...

Introduction: Dyslipidaemia is a common metabolic derangement in polycystic ovary syndrome (PCOS) and may be represented with different lipid alterations. The aim of this study was to evaluate lipid profile in different PCOS phenotypes.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (controls: 25.41±5.16 kg/m2; 30.35&...

Introduction: Insulin resistance and obesity are common features of polycystic ovary syndrome (PCOS) and both are independently associated with dysglycaemia. The aim of this study was to determine prevalence of dysglycaemia in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We evaluated 100 obese women with PCOS (PCOS group: 28.99±3.05 kg/m2; 27.70±5....

Ghrelin is a somatotrophic, orexigenic and adipogenic hormone that has an important homeostatic role by linking regulatory systems for growth and energy balance. Ghrelin- secreting neuroendocrine tumors are rare, but we had the opportunity to study a 71 years old female patient with a gastric ghrelinoma. The patient was submitted to gastroenterological examination after having episodes of diarrhea, and small subepithelial polyp (5 mm) was revealed on gastroscopy. Pathohystolog...

Cortisol rise during pregnancy is connected with fetal maturation. Together with the increase of insulin resistance it might have a role in allocation of nutrients between mother and fetus. Cortisol and insulin secretion during pregnancy seems to be induced by fluctuations in BMR. Here, we try to identify relationship between BMR and secretion of cortisol and insulin during pregnancy.In 25 healthy women (age range 20–39 years; mean±S.D.<...

A 34 year-old female patient was admitted to the hospital because of a large nodule in the left thyroid lobe and elevated calcitonine level. A large encapsulated tumor was found and total thyroidectomy with left neck dissection was performed. Pathohistology revealed medullary and papillary carcinoma separate from each other in tumor tissue but mixed in regional lymph nodes. Papillary component was dominant in thyroid tissue but not in lymph nodes. Both calcitonine and thyroglo...

Neuroendocrine tumours (NETs) have a unique ability to produce and secrete a variety of biogen amines and peptide hormones. They arise from multipotential stem cells, which differentiate during tumorigenesis into specific cell lines. Some of these tumours are functional, producing characteristic clinical syndromes. We present a female patient incidentally discovered to have diffuse liver metastases of neuroendocrine tumour of unknown primary origin. She was free of symptoms at...